Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.51 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CPS1 | P31327 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156938 | 1.00 | MTOR (0.51) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20140800 | 0.88 | CHRM2 (0.53) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20140629 | 0.87 | CHRM2 (0.49) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20139926 | 0.86 | CHRM2 (0.50) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20140022 | 0.86 | CHRM2 (0.49) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20156951 | 0.85 | MTOR (0.47) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20140908 | 0.85 | CHRM2 (0.51) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20140905 | 0.85 | CHRM2 (0.51) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20157190 | 0.84 | GRM1 (0.47) | MTORRPTORMLST8GRM1PARP1 | |
| SCHEMBL20156790 | 0.84 | CHRM2 (0.48) | MTORRPTORMLST8CHRM2GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |