Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 9/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140822 | 1.00 | ACVR1 (0.49) | ACVR1HDAC1CSNK1EGRM1FGFR1 | |
| Hydrochloric Acid SCHEMBL31046079 | 0.98 | ACVR1 (0.48) | ACVR1HDAC1CSNK1EGRM1FGFR1 | |
| SCHEMBL14186234 | 0.83 | ACVR1 (0.50) | ACVR1HDAC1FGFR1FGFR2FGFR3 | |
| SCHEMBL232428 | 0.83 | ACVR1 (0.50) | ACVR1HDAC1FGFR1FGFR2FGFR3 | |
| SCHEMBL5269599 | 0.82 | ACVR1 (0.49) | ACVR1HDAC1FGFR1FGFR2FGFR3 | |
| SCHEMBL2246752 | 0.82 | ACVR1 (0.49) | ACVR1HDAC1FGFR1FGFR2FGFR3 | |
| SCHEMBL24954334 | 0.81 | ACVR1 (0.47) | ACVR1HDAC1CSNK1EFGFR1FGFR2 | |
| SCHEMBL1472680 | 0.81 | KDM4E (0.49) | ACVR1HDAC1GPR119 | |
| SCHEMBL1470405 | 0.81 | KDM4E (0.49) | ACVR1HDAC1GPR119 | |
| SCHEMBL1470403 | 0.81 | KDM4E (0.49) | ACVR1HDAC1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |