Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 10/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 10/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 10/20 | 0.49 |
| ▸ | CALCA | P06881 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156828 | 0.91 | MTOR (0.54) | MTORRPTORMLST8CALCAKDM4E | |
| SCHEMBL20141561 | 0.88 | MTOR (0.43) | MTORRPTORMLST8CALCAPKM | |
| SCHEMBL20141564 | 0.88 | MTOR (0.43) | MTORRPTORMLST8CALCAPKM | |
| SCHEMBL20157053 | 0.88 | MTOR (0.64) | MTORRPTORMLST8CALCAKDM4E | |
| SCHEMBL20140323 | 0.87 | KDM4E (0.54) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20156994 | 0.87 | KDM4E (0.54) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20140828 | 0.86 | MTOR (0.52) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20140200 | 0.85 | MTOR (0.59) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20139966 | 0.84 | MTOR (0.61) | MTORRPTORMLST8KDM4EALDH1A1 | |
| SCHEMBL20140023 | 0.84 | MTOR (0.61) | MTORRPTORMLST8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |