Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.51 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 5/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129723 | 1.00 | MTOR (0.51) | MTORRPTORMLST8ADAM17GRM1 | |
| SCHEMBL20129721 | 1.00 | MTOR (0.51) | MTORRPTORMLST8ADAM17GRM1 | |
| SCHEMBL20129725 | 1.00 | MTOR (0.51) | MTORRPTORMLST8ADAM17GRM1 | |
| SCHEMBL20129719 | 1.00 | MTOR (0.51) | MTORRPTORMLST8ADAM17GRM1 | |
| SCHEMBL20129726 | 0.91 | MTOR (0.49) | MTORRPTORMLST8ADAM17GRM1 | |
| SCHEMBL20129722 | 0.91 | MTOR (0.49) | MTORRPTORMLST8ADAM17GRM1 | |
| SCHEMBL20129720 | 0.91 | MTOR (0.49) | MTORRPTORMLST8ADAM17GRM1 | |
| SCHEMBL20129718 | 0.91 | MTOR (0.49) | MTORRPTORMLST8ADAM17GRM1 | |
| SCHEMBL20129724 | 0.91 | MTOR (0.49) | MTORRPTORMLST8ADAM17GRM1 | |
| SCHEMBL20133578 | 0.86 | MTOR (0.65) | MTORRPTORMLST8ADAM17DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |