Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141597 | 0.82 | MTOR (0.54) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20141317 | 0.80 | MTOR (0.46) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20141403 | 0.80 | MTOR (0.43) | MTORRPTORMLST8PARP1RORC | |
| SCHEMBL20141195 | 0.79 | MTOR (0.51) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20129694 | 0.79 | MTOR (0.65) | MTORRPTORMLST8CYP1A2CYP2C9 | |
| SCHEMBL20141263 | 0.78 | MTOR (0.46) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20141210 | 0.78 | MTOR (0.65) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20140814 | 0.77 | MTOR (0.45) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20140851 | 0.77 | MTOR (0.44) | MTORRPTORMLST8CA12CA1 | |
| SCHEMBL20142302 | 0.76 | MTOR (0.55) | MTORRPTORMLST8CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |