Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.58 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.58 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20140987 | 0.91 | MTOR (0.57) | MTORRPTORMLST8FASNL3MBTL1 | |
| SCHEMBL20133555 | 0.85 | MTOR (0.64) | MTORRPTORMLST8ALDH1A1FASN | |
| SCHEMBL20133541 | 0.85 | MTOR (0.64) | MTORRPTORMLST8ALDH1A1FASN | |
| SCHEMBL20150031 | 0.84 | MTOR (0.70) | MTORRPTORMLST8FASNNAMPT | |
| SCHEMBL20133739 | 0.83 | MTOR (0.78) | MTORRPTORMLST8ALDH1A1L3MBTL1 | |
| SCHEMBL20150218 | 0.83 | MTOR (0.74) | MTORRPTORMLST8L3MBTL1KDM4E | |
| SCHEMBL22693146 | 0.80 | MTOR (0.73) | MTORRPTORMLST8FASNL3MBTL1 | |
| SCHEMBL21340100 | 0.80 | MTOR (0.64) | MTORRPTORMLST8NAMPT | |
| SCHEMBL21360358 | 0.80 | MTOR (0.64) | MTORRPTORMLST8FASNNAMPT | |
| SCHEMBL21360387 | 0.80 | MTOR (0.64) | MTORRPTORMLST8FASNNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |