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SCHEMBL20141052

SCHEMBL20141052

Cc1cc(C)c(C(=O)O)c(C)c1NC1CCN(c2ccc(F)cn2)CC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 3/20 0.58
▸ RPTOR Q8N122 3/20 0.58
▸ MLST8 Q9BVC4 3/20 0.58
▸ HRH3 Q9Y5N1 2/20 0.45
▸ PPARG P37231 1/20 0.43
▸ GPR119 Q8TDV5 1/20 0.41
▸ SMO Q99835 3/20 0.40
▸ TDO2 P48775 2/20 0.40
▸ CHRM4 P08173 1/20 0.39
▸ JAK2 O60674 4/20 0.39
▸ JAK3 P52333 4/20 0.39
▸ JAK1 P23458 3/20 0.39
▸ CA12 O43570 2/20 0.39
▸ CA1 P00915 2/20 0.39
▸ CA2 P00918 2/20 0.39
▸ CA4 P22748 2/20 0.39
▸ CA7 P43166 2/20 0.39
▸ CA9 Q16790 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ KCNH2 Q12809 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21360332 0.91 MTOR (0.57) MTORRPTORMLST8HRH3PPARG
Hydrochloric Acid SCHEMBL20141078 0.90 MTOR (0.56) MTORRPTORMLST8HRH3PPARG
SCHEMBL22187985 0.90 MTOR (0.65) MTORRPTORMLST8HRH3PPARG
SCHEMBL20141276 0.87 MTOR (0.54) MTORRPTORMLST8HRH3PPARG
SCHEMBL22187892 0.86 MTOR (0.53) MTORRPTORMLST8HRH3PPARG
SCHEMBL22188069 0.84 MTOR (0.63) MTORRPTORMLST8HRH3KDM4E
SCHEMBL22187869 0.84 MTOR (0.60) MTORRPTORMLST8HRH3KDM4E
SCHEMBL21360417 0.83 MTOR (0.50) MTORRPTORMLST8HRH3GPR119
SCHEMBL21340110 0.82 MTOR (0.65) MTORRPTORMLST8HRH3SMO
SCHEMBL20141622 0.82 MTOR (0.85) MTORRPTORMLST8HRH3PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2020-11-24 — — US disclosed
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2020-07-02 — — US disclosed
EP-3538091-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF Navitor Pharmaceuticals, Inc. (US) 2019-09-18 — — EP disclosed
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2019-09-17 — — US disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.