Sugi Predict

Sugi Predict / Compounds / SCHEMBL20141071

SCHEMBL20141071

SCHEMBL20141071

COC(=O)c1ccc(C)c(NC2CCN(c3ccccc3C#N)CC2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 6/20 0.53
▸ RPTOR Q8N122 6/20 0.53
▸ MLST8 Q9BVC4 6/20 0.53
▸ MAPT P10636 2/20 0.45
▸ HPGD P15428 2/20 0.45
▸ KMT2A Q03164 2/20 0.45
▸ CYP1A2 P05177 2/20 0.45
▸ CYP3A4 P08684 2/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ DRD4 P21917 4/20 0.44
▸ DRD2 P14416 2/20 0.44
▸ DRD3 P35462 2/20 0.44
▸ ALDH1A1 P00352 5/20 0.43
▸ KDM4E B2RXH2 4/20 0.43
▸ NPC1 O15118 2/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ HDAC8 Q9BY41 1/20 0.42
▸ CYP2D6 P10635 1/20 0.42
▸ HTR2A P28223 1/20 0.42
▸ THPO P40225 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20140924 0.90 MTOR (0.55) MTORRPTORMLST8CYP1A2CYP3A4
SCHEMBL20129666 0.88 MTOR (0.62) MTORRPTORMLST8MAPTHPGD
SCHEMBL20133548 0.86 MTOR (0.56) MTORRPTORMLST8MAPTHPGD
SCHEMBL20133701 0.84 MTOR (0.61) MTORRPTORMLST8KMT2ADRD4
SCHEMBL20133693 0.84 MTOR (0.54) MTORRPTORMLST8MAPTHPGD
SCHEMBL20129692 0.84 MTOR (0.47) MTORRPTORMLST8CYP1A2CYP3A4
SCHEMBL22187976 0.84 MTOR (0.58) MTORRPTORMLST8MAPTALDH1A1
SCHEMBL20141296 0.83 MTOR (0.53) MTORRPTORMLST8KMT2ACYP1A2
SCHEMBL20129693 0.83 MTOR (0.61) MTORRPTORMLST8KMT2AALDH1A1
SCHEMBL20133856 0.82 MTOR (0.56) MTORRPTORMLST8KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2020-11-24 — — US disclosed
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2020-07-02 — — US disclosed
EP-3538091-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF Navitor Pharmaceuticals, Inc. (US) 2019-09-18 — — EP disclosed
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2019-09-17 — — US disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.