Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.51 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133545 | 0.79 | MTOR (0.68) | MTORRPTORMLST8GRM1AVPR1A | |
| SCHEMBL20141354 | 0.79 | MTOR (0.68) | MTORRPTORMLST8GRM1AVPR1A | |
| SCHEMBL20133655 | 0.79 | MTOR (0.68) | MTORRPTORMLST8GRM1AVPR1A | |
| SCHEMBL22693157 | 0.76 | MTOR (0.49) | MTORRPTORMLST8GRM1AVPR1A | |
| SCHEMBL21360293 | 0.70 | MTOR (0.81) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL22693153 | 0.70 | MTOR (0.81) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL20141042 | 0.70 | MTOR (0.81) | MTORRPTORMLST8ALDH1A1 | |
| SCHEMBL21340104 | 0.69 | MTOR (0.58) | MTORRPTORMLST8GRM1AVPR1A | |
| SCHEMBL22693238 | 0.69 | MTOR (0.56) | MTORRPTORMLST8GRM1AVPR1A | |
| SCHEMBL20140855 | 0.68 | GRM1 (0.67) | GRM1AVPR1ASMN1; SMN2SLC6A7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |