Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 9/20 | 0.77 |
| ▸ | RPTOR | Q8N122 | 9/20 | 0.77 |
| ▸ | MLST8 | Q9BVC4 | 9/20 | 0.77 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | MC2R | Q01718 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133790 | 1.00 | MTOR (0.77) | MTORRPTORMLST8HSD11B1DPP4 | |
| SCHEMBL21360389 | 0.94 | MTOR (0.76) | MTORRPTORMLST8DPP4HCRTR1 | |
| SCHEMBL20141220 | 0.94 | MTOR (0.76) | MTORRPTORMLST8DPP4HCRTR1 | |
| SCHEMBL21360294 | 0.94 | MTOR (0.76) | MTORRPTORMLST8DPP4HCRTR1 | |
| SCHEMBL21360392 | 0.93 | MTOR (0.75) | MTORRPTORMLST8HSD11B1DPP4 | |
| SCHEMBL20140844 | 0.93 | MTOR (0.75) | MTORRPTORMLST8HSD11B1DPP4 | |
| SCHEMBL20141344 | 0.92 | MTOR (0.82) | MTORRPTORMLST8DPP4PARP1 | |
| SCHEMBL21360360 | 0.92 | MTOR (0.82) | MTORRPTORMLST8DPP4PARP1 | |
| SCHEMBL21360288 | 0.92 | MTOR (0.80) | MTORRPTORMLST8DPP4ALDH1A1 | |
| SCHEMBL21360321 | 0.92 | MTOR (0.80) | MTORRPTORMLST8DPP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538091-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2019-09-18 | — | — | EP | disclosed |
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |