Sugi Predict

Sugi Predict / Compounds / SCHEMBL20141235

SCHEMBL20141235

SCHEMBL20141235

Cc1cc(C)c(C(=O)N2CCN(c3ccccc3)[C@H](CN)C2)c(C)c1NC1CCN(c2ccccc2C#N)CC1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MTOR P42345 10/20 0.68
▸ RPTOR Q8N122 10/20 0.68
▸ MLST8 Q9BVC4 10/20 0.68
▸ DRD4 P21917 3/20 0.36
▸ DPP4 P27487 1/20 0.34
▸ ADAM17 P78536 2/20 0.34
▸ GRM1 Q13255 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ CYP2D6 P10635 1/20 0.34
▸ DRD2 P14416 1/20 0.34
▸ HTR2A P28223 1/20 0.34
▸ DRD3 P35462 1/20 0.34
▸ THPO P40225 1/20 0.34
▸ HIF1A Q16665 1/20 0.34
▸ HCRTR1 O43613 1/20 0.34
▸ HCRTR2 O43614 1/20 0.34
▸ HTR1A P08908 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21360364 1.00 MTOR (0.68) MTORRPTORMLST8DRD4DPP4
SCHEMBL20141279 0.93 MTOR (0.67) MTORRPTORMLST8DRD4ADAM17
SCHEMBL21360408 0.93 MTOR (0.67) MTORRPTORMLST8DRD4ADAM17
SCHEMBL21340102 0.89 MTOR (0.84) MTORRPTORMLST8DRD4DPP4
SCHEMBL21360350 0.88 MTOR (0.62) MTORRPTORMLST8DRD4DRD2
SCHEMBL20141375 0.88 MTOR (0.62) MTORRPTORMLST8DRD4DRD2
SCHEMBL20133757 0.88 MTOR (0.62) MTORRPTORMLST8
SCHEMBL22693142 0.87 MTOR (0.74) MTORRPTORMLST8DPP4
SCHEMBL20133544 0.86 MTOR (0.63) MTORRPTORMLST8DRD4DPP4
SCHEMBL20141518 0.86 MTOR (0.63) MTORRPTORMLST8DRD4DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2020-11-24 — — US disclosed
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. 2020-07-02 — — US disclosed
EP-3538091-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF Navitor Pharmaceuticals, Inc. (US) 2019-09-18 — — EP disclosed
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof NAVITOR PHARMACEUTICALS, INC. (US) 2019-09-17 — — US disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10844013-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-10414727-B2 Phenyl amino piperidine mTORC inhibitors and uses thereof MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885
US-20200207716-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885RPTOR 3/4885MLST8 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.