Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 3/20 | 0.59 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15933524 | 0.77 | PDCD1 (0.50) | PDCD1CD274CYP3A4TLR8TLR7 | |
| SCHEMBL15933521 | 0.76 | PDCD1 (0.69) | PDCD1CD274LMNAMAPTHPGD | |
| SCHEMBL15933691 | 0.75 | PDCD1 (0.55) | PDCD1CD274CYP1A2CYP3A4LMNA | |
| SCHEMBL19549671 | 0.74 | CD274 (1.00) | PDCD1CD274LMNAMAPTTLR8 | |
| SCHEMBL15933680 | 0.72 | PDCD1 (0.46) | PDCD1CD274KDM4EKMT2ATLR8 | |
| SCHEMBL505515 | 0.71 | PDCD1 (0.53) | PDCD1CD274KDM4ELMNAKMT2A | |
| SCHEMBL24689593 | 0.70 | PDCD1 (0.41) | PDCD1CD274TLR8TLR7 | |
| SCHEMBL15933623 | 0.70 | PDCD1 (0.44) | PDCD1CD274TLR8TLR7 | |
| SCHEMBL15933689 | 0.69 | PDCD1 (0.51) | PDCD1CD274TLR8TLR7SLC6A2 | |
| SCHEMBL5112559 | 0.69 | PDCD1 (0.53) | PDCD1CD274TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |