Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 6/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20139926 | 0.95 | CHRM2 (0.50) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20157088 | 0.88 | MTOR (0.49) | MTORRPTORMLST8HTR1AHTR2A | |
| SCHEMBL20140721 | 0.87 | GRM1 (0.45) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20157490 | 0.87 | GRM1 (0.45) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20140800 | 0.87 | CHRM2 (0.53) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20141016 | 0.85 | MTOR (0.53) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20140905 | 0.84 | CHRM2 (0.51) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20140908 | 0.84 | CHRM2 (0.51) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20141878 | 0.82 | MTOR (0.44) | MTORRPTORMLST8CHRM2GRM1 | |
| SCHEMBL20140022 | 0.82 | CHRM2 (0.49) | MTORRPTORMLST8CHRM2GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |