Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.78 |
| ▸ | GSK3B | P49841 | 2/20 | 0.78 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.62 |
| ▸ | CDK2 | P24941 | 7/20 | 0.62 |
| ▸ | DHODH | Q02127 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TUBB8B | A6NNZ2 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.52 |
| ▸ | TUBB | P07437 | 1/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142463 | 0.89 | GSK3A (0.89) | GSK3AGSK3BCCNA2CDK2NPC1 | |
| SCHEMBL20142416 | 0.89 | GSK3A (0.62) | GSK3AGSK3BCCNA2CDK2DHODH | |
| SCHEMBL20142068 | 0.88 | GSK3A (1.00) | GSK3AGSK3BCCNA2CDK2NPC1 | |
| SCHEMBL20142500 | 0.86 | GSK3A (0.77) | GSK3AGSK3BCCNA2CDK2NPC1 | |
| SCHEMBL20142401 | 0.85 | GSK3A (0.58) | GSK3AGSK3BCCNA2CDK2DHODH | |
| SCHEMBL20142196 | 0.84 | GSK3A (0.81) | GSK3AGSK3BCCNA2CDK2NPC1 | |
| SCHEMBL20142382 | 0.84 | MEN1 (0.83) | GSK3AGSK3BCCNA2CDK2NPC1 | |
| SCHEMBL20142470 | 0.84 | GSK3A (0.80) | GSK3AGSK3BCCNA2CDK2NPC1 | |
| SCHEMBL20142290 | 0.84 | GSK3A (0.80) | GSK3AGSK3BCCNA2CDK2NPC1 | |
| SCHEMBL20141891 | 0.84 | GSK3A (0.80) | GSK3AGSK3BCCNA2CDK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089902-A1 | DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2018-05-17 | — | — | WO | claimed |
| WO-2018089902-A1 | DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |