Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 10/20 | 0.77 |
| ▸ | CDK2 | P24941 | 10/20 | 0.77 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.69 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13633843 | 0.90 | CCNA2 (0.78) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL20142491 | 0.87 | CDK5 (0.65) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL20142431 | 0.87 | CCNA2 (0.72) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL25609597 | 0.87 | MAPT (0.78) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL20142200 | 0.86 | CCNA2 (0.81) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL20142166 | 0.85 | CCNA2 (0.66) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL4477981 | 0.84 | CDK5 (0.81) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL4465180 | 0.82 | CCNA2 (0.82) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL7756943 | 0.82 | MAPT (0.78) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL20141898 | 0.82 | CDK5 (0.71) | CCNA2CDK2CDK5CDK5R1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089902-A1 | DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2018-05-17 | — | — | WO | claimed |
| WO-2018089902-A1 | DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |