SCHEMBL20142369

SCHEMBL20142369

Cc1cc(C)c(C(=O)N2CCN(c3cc(F)ccn3)C(CO)C2)cc1NC1CCN(c2ccccc2C#N)CC1

nearest known ligand 0.79

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MTOR P42345 10/20 0.79
RPTOR Q8N122 10/20 0.79
MLST8 Q9BVC4 10/20 0.79
HCRTR1 O43613 7/20 0.39
HCRTR2 O43614 7/20 0.39
SYK P43405 1/20 0.36
DPP4 P27487 1/20 0.36
GPR6 P46095 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20133841 1.00 MTOR (0.79) MTORRPTORMLST8HCRTR1HCRTR2
SCHEMBL20133536 1.00 MTOR (0.79) MTORRPTORMLST8HCRTR1HCRTR2
SCHEMBL20141042 0.92 MTOR (0.81) MTORRPTORMLST8HCRTR1HCRTR2
SCHEMBL22693153 0.92 MTOR (0.81) MTORRPTORMLST8HCRTR1HCRTR2
SCHEMBL21360293 0.92 MTOR (0.81) MTORRPTORMLST8HCRTR1HCRTR2
SCHEMBL20149890 0.90 MTOR (0.77) MTORRPTORMLST8HCRTR1HCRTR2
SCHEMBL20133742 0.90 MTOR (0.77) MTORRPTORMLST8HCRTR1HCRTR2
SCHEMBL20133667 0.90 MTOR (0.77) MTORRPTORMLST8HCRTR1HCRTR2
SCHEMBL20141344 0.88 MTOR (0.82) MTORRPTORMLST8DPP4
SCHEMBL21360360 0.88 MTOR (0.82) MTORRPTORMLST8DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3538091-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF Navitor Pharmaceuticals, Inc. (US) 2019-09-18 EP disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 WO disclosed
WO-2018089499-A1 PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF NAVITOR PHARMACEUTICALS, INC. (US) 2018-05-17 WO disclosed