Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.79 |
| ▸ | MEN1 | O00255 | 4/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.79 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.78 |
| ▸ | CDK2 | P24941 | 7/20 | 0.78 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.76 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.76 |
| ▸ | MAPT | P10636 | 4/20 | 0.76 |
| ▸ | TP53 | P04637 | 2/20 | 0.76 |
| ▸ | GSK3A | P49840 | 2/20 | 0.73 |
| ▸ | GSK3B | P49841 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25609657 | 1.00 | NPC1 (0.79) | NPC1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL13633841 | 0.94 | CCNA2 (0.88) | NPC1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL25611327 | 0.88 | NPC1 (0.76) | NPC1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL25609654 | 0.88 | MEN1 (1.00) | NPC1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL20142856 | 0.88 | MEN1 (1.00) | NPC1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL25610719 | 0.88 | NPC1 (0.76) | NPC1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL20142192 | 0.88 | CCNA2 (0.78) | NPC1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL20142403 | 0.88 | CCNA2 (0.78) | NPC1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL25609762 | 0.88 | CCNA2 (0.78) | NPC1MEN1KMT2ACCNA2CDK2 | |
| SCHEMBL20142846 | 0.88 | CCNA2 (0.78) | NPC1MEN1KMT2ACCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089902-A1 | DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2018-05-17 | — | — | WO | claimed |
| WO-2018089902-A1 | DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | APOGEE BIOTECHNOLOGY CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |