Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | TET3 | O43151 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.30 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.30 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.30 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.30 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.30 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29333077 | 0.79 | KMT2A (0.35) | KRASTSHRJAK3TET3KMT2A | |
| SCHEMBL24092956 | 0.77 | TET3 (0.33) | KRASTSHRJAK3TET3KMT2A | |
| SCHEMBL20148575 | 0.77 | SMN1; SMN2 (0.45) | PIK3CDALDH1A1 | |
| SCHEMBL24829662 | 0.74 | TET3 (0.36) | KRASJAK3TET3KMT2AFBXL19 | |
| SCHEMBL25844825 | 0.74 | JAK3 (0.32) | KRASJAK3TET3KMT2AFBXL19 | |
| SCHEMBL23682421 | 0.73 | TET3 (0.33) | KRASTSHRJAK3TET3KMT2A | |
| SCHEMBL22699586 | 0.71 | JAK3 (0.33) | KRASTSHRJAK3TET3KMT2A | |
| SCHEMBL24497417 | 0.70 | KMT2A (0.40) | JAK3TET3KMT2AFBXL19CXXC5 | |
| SCHEMBL21958804 | 0.70 | KMT2A (0.40) | JAK3TET3KMT2AFBXL19CXXC5 | |
| SCHEMBL22833078 | 0.70 | KMT2A (0.36) | JAK3TET3KMT2AFBXL19CXXC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970300-B1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-05-16 | — | — | EP | disclosed |