Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.64 |
| ▸ | EGFR | P00533 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | ITK | Q08881 | 1/20 | 0.59 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.58 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21338891 | 0.91 | BTK (0.76) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL17951556 | 0.90 | BTK (0.73) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL20144246 | 0.89 | BTK (0.60) | BTKEGFRLCKITK | |
| SCHEMBL16075002 | 0.88 | BTK (0.76) | BTK | |
| SCHEMBL16074999 | 0.87 | BTK (0.77) | BTK | |
| SCHEMBL16075001 | 0.87 | BTK (0.77) | BTK | |
| SCHEMBL16123023 | 0.87 | BTK (0.77) | BTK | |
| SCHEMBL22720698 | 0.87 | BTK (0.69) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL22720690 | 0.87 | BTK (0.69) | BTKEGFRLCKITKNUDT14 | |
| SCHEMBL5801559 | 0.87 | BTK (0.69) | BTKEGFRLCKITKNUDT14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970300-B1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-05-16 | — | — | EP | disclosed |