Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.91 |
| ▸ | ITK | Q08881 | 4/20 | 0.69 |
| ▸ | EGFR | P00533 | 4/20 | 0.69 |
| ▸ | LCK | P06239 | 3/20 | 0.69 |
| ▸ | FGR | P09769 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | CSK | P41240 | 1/20 | 0.64 |
| ▸ | BLK | P51451 | 1/20 | 0.64 |
| ▸ | JAK3 | P52333 | 1/20 | 0.64 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.59 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20177225 | 0.95 | BTK (1.00) | BTKITKEGFRLCKFGR | |
| SCHEMBL20177303 | 0.95 | BTK (1.00) | BTKITKEGFRLCKFGR | |
| SCHEMBL21330605 | 0.95 | BTK (1.00) | BTKITKEGFRLCKFGR | |
| SCHEMBL21330631 | 0.91 | BTK (0.91) | BTKITKEGFRLCKFGR | |
| SCHEMBL21330635 | 0.91 | BTK (0.91) | BTKITKEGFRLCKFGR | |
| SCHEMBL30331082 | 0.89 | BTK (0.78) | BTKITKEGFRLCKFGR | |
| SCHEMBL16074992 | 0.89 | BTK (1.00) | BTKITKEGFRLCKFGR | |
| SCHEMBL18211765 | 0.86 | BTK (0.91) | BTKITKEGFRLCKFGR | |
| SCHEMBL18211764 | 0.86 | BTK (0.91) | BTKITKEGFRLCKFGR | |
| SCHEMBL18211763 | 0.86 | BTK (0.91) | BTKITKEGFRLCKFGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970300-B1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2018-05-16 | — | — | EP | disclosed |