Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | LDLR | P01130 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.49 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 4/20 | 0.47 |
| ▸ | BCR | P11274 | 4/20 | 0.47 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15442439 | 0.91 | KIT (0.54) | BRAFLDLRKITPCSK9NR2E1 | |
| SCHEMBL19891274 | 0.88 | KIT (0.56) | BRAFLDLRKITPCSK9NR2E1 | |
| SCHEMBL15442426 | 0.85 | MAPT (0.47) | BRAFLDLRKITPCSK9NR2E1 | |
| SCHEMBL29958875 | 0.83 | PSEN1 (0.52) | NR2E1CSF1RPSEN1PSEN2APH1B | |
| SCHEMBL2679904 | 0.81 | BRAF (0.49) | BRAFKITCSF1REPHB2ABL1 | |
| SCHEMBL10077762 | 0.81 | BRAF (0.49) | BRAFKITCSF1REPHB2ABL1 | |
| SCHEMBL13659898 | 0.79 | NR2E1 (0.77) | LDLRKITPCSK9NR2E1EPHB2 | |
| SCHEMBL2679720 | 0.79 | ABL1 (0.50) | BRAFLDLRKITPCSK9CSF1R | |
| SCHEMBL10077754 | 0.79 | ABL1 (0.50) | BRAFLDLRKITPCSK9CSF1R | |
| SCHEMBL15442334 | 0.79 | ABL1 (0.54) | KITCSF1RABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186247-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-2880038-B1 | PROTEIN KINASE INHIBITORS | ASTAR BIOTECH LLC (US) | 2018-05-16 | — | — | EP | disclosed |