SCHEMBL20144775

SCHEMBL20144775

Nc1ccc2c(c1)N(CCNCCCN1CCCOCC1)CCC2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 3/20 0.41
HRH3 Q9Y5N1 2/20 0.39
CYP2C19 P33261 2/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
ALOX15 P16050 2/20 0.38
HPGD P15428 1/20 0.38
HTT P42858 1/20 0.38
CYP2C9 P11712 1/20 0.38
ALDH1A1 P00352 1/20 0.37
PAOX Q6QHF9 1/20 0.37
MAPT P10636 3/20 0.36
TP53 P04637 1/20 0.36
THRB P10828 1/20 0.36
RECQL P46063 1/20 0.35
KDM4E B2RXH2 2/20 0.35
ACP1 P24666 1/20 0.35
TSHR P16473 1/20 0.35
HSD17B10 Q99714 1/20 0.35
KMT2A Q03164 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15037980 0.97 KDM1A (0.43) KDM1AHRH3CYP2C19CYP3A4CYP2D6
SCHEMBL15038014 0.91 KDM1A (0.42) KDM1AHRH3CYP3A4ALOX15HPGD
SCHEMBL15037984 0.90 HRH3 (0.46) KDM1AHRH3CYP3A4
SCHEMBL15037987 0.89 HRH3 (0.48) KDM1AHRH3CYP3A4MAPTRECQL
SCHEMBL15037985 0.86 HRH3 (0.42) KDM1AHRH3CYP3A4ALDH1A1MAPT
SCHEMBL15038009 0.84 HRH3 (0.44) KDM1AHRH3CYP3A4ALDH1A1KMT2A
SCHEMBL4422995 0.84 BRD4 (0.42) HRH3ALOX15HPGDHTTALDH1A1
SCHEMBL15038011 0.83 HRH3 (0.46) KDM1AHRH3CYP3A4ALDH1A1KMT2A
SCHEMBL15037578 0.82 HRH3 (0.40) HRH3CYP3A4ALDH1A1KMT2AMEN1
SCHEMBL15037982 0.81 HRH3 (0.47) HRH3CYP3A4ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2791116-B1 COUPLER WITH 7-AMINO-1,2,3,4-TETRAHYDROQUINOLINE STRUCTURE, DYEING COMPOSITION COMPRISING SAME, PROCESSES AND USES OREAL (FR) 2018-05-16 EP disclosed