Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 12/20 | 0.69 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18697845 | 1.00 | HCRTR1 (0.69) | HCRTR1HCRTR2PROKR1LMNAMEN1 | |
| SCHEMBL20144792 | 0.90 | HCRTR1 (0.55) | HCRTR1HCRTR2PROKR1 | |
| SCHEMBL20145099 | 0.90 | HCRTR1 (0.55) | HCRTR1HCRTR2PROKR1 | |
| SCHEMBL20145062 | 0.87 | HCRTR1 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL18697838 | 0.87 | HCRTR1 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL20144876 | 0.86 | HCRTR1 (0.69) | HCRTR1HCRTR2PROKR1 | |
| SCHEMBL20145259 | 0.85 | HCRTR1 (0.69) | HCRTR1HCRTR2 | |
| SCHEMBL20144787 | 0.85 | HCRTR1 (0.69) | HCRTR1HCRTR2 | |
| SCHEMBL18697568 | 0.83 | HCRTR1 (0.53) | HCRTR1HCRTR2PROKR1 | |
| SCHEMBL20144994 | 0.83 | HCRTR1 (0.53) | HCRTR1HCRTR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |