Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | CCNK | O75909 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144832 | 0.90 | HCRTR2 (0.45) | KMT2AHCRTR1GAAHCRTR2 | |
| SCHEMBL20145258 | 0.90 | HCRTR2 (0.45) | KMT2AHCRTR1GAAHCRTR2 | |
| SCHEMBL16147941 | 0.82 | HCRTR1 (0.64) | HCRTR1HCRTR2 | |
| SCHEMBL20144834 | 0.78 | HCRTR1 (0.71) | HCRTR1GAAHCRTR2 | |
| SCHEMBL20144867 | 0.77 | HCRTR1 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL20144731 | 0.76 | HCRTR1 (0.71) | HCRTR1HCRTR2 | |
| SCHEMBL20144982 | 0.75 | HCRTR1 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL25226590 | 0.74 | MAPK3 (0.50) | CDK12BTKCCNKKMT2AHCRTR1 | |
| SCHEMBL16155578 | 0.74 | HCRTR2 (0.67) | HCRTR1HCRTR2 | |
| SCHEMBL20145032 | 0.74 | HCRTR1 (0.71) | CDK12CCNKHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |