Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18124635 | 0.90 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBCYP1A2CYP2D6MAPT | |
| SCHEMBL18124672 | 0.90 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBCYP1A2CYP2D6MAPT | |
| SCHEMBL18124654 | 0.90 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBCYP1A2CYP2D6MAPT | |
| SCHEMBL18125091 | 0.84 | MAPT (0.69) | SMN1; SMN2POLBCYP1A2CYP2D6MAPT | |
| SCHEMBL18125081 | 0.84 | MAPT (0.69) | SMN1; SMN2POLBCYP1A2CYP2D6MAPT | |
| SCHEMBL18125100 | 0.84 | MAPT (0.69) | SMN1; SMN2POLBCYP1A2CYP2D6MAPT | |
| SCHEMBL18638555 | 0.83 | POLB (0.56) | SMN1; SMN2POLBCYP1A2CYP2D6MAPT | |
| SCHEMBL18664499 | 0.83 | POLB (0.56) | SMN1; SMN2POLBCYP1A2CYP2D6MAPT | |
| SCHEMBL18638511 | 0.83 | POLB (0.56) | SMN1; SMN2POLBCYP1A2CYP2D6MAPT | |
| SCHEMBL11814069 | 0.82 | SMN1; SMN2 (0.59) | SMN1; SMN2POLBCYP1A2CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3722297-A1 | TOLL-LIKE RECEPTOR MODULATING 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS | Gilead Sciences, Inc. (US) | 2020-10-14 | — | — | EP | disclosed |
| EP-3321265-A1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR UTILISATION AS MODULATORS OF TOLL-LIKE RECEPTORS | Gilead Sciences, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |