Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 17/20 | 0.79 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18124768 | 1.00 | TLR8 (0.79) | TLR8TLR7KCNH2 | |
| SCHEMBL18109694 | 1.00 | TLR8 (0.79) | TLR8TLR7KCNH2 | |
| SCHEMBL18109615 | 0.91 | TLR8 (0.82) | TLR8TLR7KCNH2 | |
| SCHEMBL18109612 | 0.91 | TLR8 (0.82) | TLR8TLR7KCNH2 | |
| SCHEMBL18109279 | 0.88 | TLR8 (1.00) | TLR8TLR7KCNH2 | |
| SCHEMBL18109277 | 0.88 | TLR8 (1.00) | TLR8TLR7KCNH2 | |
| SCHEMBL18124727 | 0.88 | TLR8 (1.00) | TLR8TLR7KCNH2 | |
| SCHEMBL18109625 | 0.87 | TLR8 (0.83) | TLR8TLR7KCNH2 | |
| SCHEMBL18109379 | 0.85 | TLR8 (1.00) | TLR8TLR7KCNH2 | |
| SCHEMBL18109380 | 0.85 | TLR8 (1.00) | TLR8TLR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321265-A1 | 4,6-DIAMINO-PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS AND THEIR UTILISATION AS MODULATORS OF TOLL-LIKE RECEPTORS | Gilead Sciences, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |