Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 8/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20145569 | 0.83 | PDGFRB (0.50) | MAPK1MEN1HCRTR1KMT2APOLB | |
| SCHEMBL20145650 | 0.83 | MAPK1 (0.71) | MAPK1 | |
| SCHEMBL16679914 | 0.81 | MAPK1 (0.71) | MAPK1 | |
| SCHEMBL16679910 | 0.81 | MAPK1 (0.71) | MAPK1 | |
| SCHEMBL20145464 | 0.75 | MAPK1 (0.73) | MAPK1 | |
| SCHEMBL20145784 | 0.75 | MAPK1 (0.73) | MAPK1 | |
| SCHEMBL20145583 | 0.75 | MAPK1 (0.73) | MAPK1 | |
| SCHEMBL18112983 | 0.74 | MKNK1 (0.49) | MAP4K4 | |
| SCHEMBL20145561 | 0.74 | MAPK1 (0.72) | MAPK1 | |
| SCHEMBL20145579 | 0.74 | MAPK1 (0.73) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063143-B1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2018-05-16 | — | — | EP | disclosed |