Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | SMO | Q99835 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15424144 | 0.91 | MEN1 (0.64) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL15424152 | 0.83 | MAPT (0.65) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL15424140 | 0.83 | MEN1 (0.73) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL15558259 | 0.80 | MEN1 (0.71) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL14642442 | 0.79 | MEN1 (0.79) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL15424177 | 0.79 | MEN1 (0.53) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL13679611 | 0.78 | MEN1 (0.74) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL19128872 | 0.78 | MEN1 (0.50) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL19916743 | 0.78 | MAPT (0.52) | MEN1KMT2AHTTMAPTKDM4E | |
| SCHEMBL15557984 | 0.78 | MEN1 (0.68) | MEN1KMT2AHTTMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321261-B1 | HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES | CURIS INC (US) | 2020-06-17 | — | — | EP | disclosed |
| EP-3321261-A1 | HEDGEHOG ANTAGONISTS HAVING ZINC BINDING MOIETIES | Curis, Inc. (US) | 2018-05-16 | — | — | EP | disclosed |