Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 17/20 | 0.46 |
| ▸ | NEK2 | P51955 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16679329 | 0.88 | MAPK1 (0.43) | MAPK1NEK2 | |
| SCHEMBL28256472 | 0.86 | NEK2 (0.44) | MAPK1NEK2 | |
| SCHEMBL16679356 | 0.85 | MAPK1 (0.42) | MAPK1NEK2PIK3CA | |
| SCHEMBL16680394 | 0.83 | PIK3CA (0.38) | MAPK1PIK3CA | |
| SCHEMBL21264417 | 0.83 | MAPK1 (0.51) | MAPK1NEK2 | |
| SCHEMBL16690899 | 0.82 | MAPK1 (0.61) | MAPK1 | |
| SCHEMBL16679119 | 0.82 | MAPK1 (0.61) | MAPK1 | |
| SCHEMBL16680152 | 0.82 | MAPK1 (0.74) | MAPK1 | |
| SCHEMBL16679631 | 0.82 | MAPK1 (0.46) | MAPK1NEK2PIK3CDHTR1APIK3R1 | |
| SCHEMBL16679278 | 0.82 | MAPK1 (0.57) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063143-B1 | AMINOHETEROARYL BENZAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2018-05-16 | — | — | EP | disclosed |