Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.52 |
| ▸ | FYN | P06241 | 11/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20146788 | 0.87 | MKNK1 (0.52) | MKNK1MKNK2FYNCYP3A4GRK5 | |
| SCHEMBL15288743 | 0.82 | MKNK1 (0.56) | MKNK1MKNK2FYNCYP3A4CHEK1 | |
| SCHEMBL19243695 | 0.82 | MKNK1 (0.60) | MKNK1MKNK2FYNCYP3A4CHEK1 | |
| SCHEMBL20146888 | 0.81 | MKNK1 (0.52) | MKNK1MKNK2FYNCYP3A4 | |
| SCHEMBL16331348 | 0.81 | FYN (0.70) | MKNK1MKNK2FYNCHEK1GSK3B | |
| SCHEMBL16331186 | 0.77 | MKNK1 (0.69) | MKNK1MKNK2FYNCHEK1GSK3B | |
| SCHEMBL16304085 | 0.76 | MKNK1 (0.52) | MKNK1MKNK2FYNCYP3A4CHEK1 | |
| SCHEMBL16304099 | 0.76 | MKNK1 (0.49) | MKNK1MKNK2FYNCYP3A4CHEK1 | |
| SCHEMBL15288456 | 0.75 | MKNK1 (0.50) | MKNK1MKNK2FYNCYP3A4CHEK1 | |
| SCHEMBL15288103 | 0.74 | MKNK1 (0.70) | MKNK1MKNK2FYNCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3321268-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | Agency For Science, Technology And Research (SG) | 2018-05-16 | — | — | EP | disclosed |