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SCHEMBL20147547

SCHEMBL20147547

CC1(NC(=O)c2cccc(F)c2F)CCN(C(C)(C)C)C1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ RET P07949 5/20 0.43
▸ HPGD P15428 1/20 0.40
▸ USP30 Q70CQ3 1/20 0.38
▸ CES2 O00748 2/20 0.38
▸ CES1 P23141 2/20 0.38
▸ BCHE P06276 1/20 0.38
▸ HSD11B1 P28845 1/20 0.37
▸ KAT6A Q92794 2/20 0.36
▸ CCR3 P51677 1/20 0.36
▸ HCRTR1 O43613 1/20 0.35
▸ HCRTR2 O43614 1/20 0.35
▸ DRD2 P14416 2/20 0.35
▸ P2RX7 Q99572 1/20 0.35
▸ ATM Q13315 1/20 0.34
▸ DPP4 P27487 1/20 0.34
▸ SLC6A9 P48067 1/20 0.33
▸ HTR1A P08908 1/20 0.33
▸ HTR7 P34969 1/20 0.33
▸ HTR6 P50406 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22857088 0.90 GAA (0.43) RETUSP30KAT6ACCR3SLC6A9
SCHEMBL20147545 0.86 RET (0.41) RETUSP30
SCHEMBL20147980 0.83 GAA (0.45) RETHPGDCCR3ATMDPP4
SCHEMBL20068944 0.81 HPGD (0.44) RETHPGDUSP30CES2CES1
SCHEMBL20158868 0.81 CCR3 (0.42) RETHPGDUSP30CES2CES1
SCHEMBL20152065 0.81 HPGD (0.40) RETHPGDUSP30CES2CES1
SCHEMBL20147614 0.79 RET (0.45) RETUSP30
SCHEMBL20147554 0.79 RET (0.45) RETUSP30CCR3P2RX7
SCHEMBL20147565 0.78 HPGD (0.42) RETHPGDCES2CES1BCHE
SCHEMBL20147548 0.77 MCHR1 (0.42) RETATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10881652-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2021-01-05 — — US disclosed
US-10441581-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2019-10-15 — — US disclosed
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-31 — — US disclosed
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-31 — — US disclosed
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10881652-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 RET 1/4885HPGD 3857/4885USP30 2944/4885
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 RET 1/4885HPGD 3857/4885USP30 2944/4885
US-10441581-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 RET 1/4885HPGD 3857/4885USP30 2944/4885
US-20180133207-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 RET 1/4885HPGD 3857/4885USP30 2944/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.