Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.62 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.62 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.62 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133681 | 0.97 | MTOR (0.65) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20150218 | 0.89 | MTOR (0.74) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20129637 | 0.87 | MTOR (0.64) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20129666 | 0.85 | MTOR (0.62) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20133739 | 0.85 | MTOR (0.78) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL22693146 | 0.82 | MTOR (0.73) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20133858 | 0.81 | MTOR (0.58) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20149902 | 0.81 | MTOR (0.72) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL21360385 | 0.81 | MTOR (0.72) | MTORRPTORMLST8DRD2DRD3 | |
| SCHEMBL20150031 | 0.81 | MTOR (0.70) | MTORRPTORMLST8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |