Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.70 |
| ▸ | RPTOR | Q8N122 | 8/20 | 0.70 |
| ▸ | MLST8 | Q9BVC4 | 8/20 | 0.70 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133642 | 1.00 | MTOR (0.70) | MTORRPTORMLST8MC4RDPP4 | |
| SCHEMBL20133656 | 1.00 | MTOR (0.70) | MTORRPTORMLST8MC4RDPP4 | |
| SCHEMBL21360321 | 0.90 | MTOR (0.80) | MTORRPTORMLST8DPP4DRD4 | |
| SCHEMBL21360288 | 0.90 | MTOR (0.80) | MTORRPTORMLST8DPP4DRD4 | |
| SCHEMBL22693123 | 0.89 | MTOR (0.58) | MTORRPTORMLST8 | |
| SCHEMBL20133553 | 0.88 | MTOR (0.77) | MTORRPTORMLST8DPP4DRD4 | |
| SCHEMBL20133690 | 0.88 | MTOR (0.77) | MTORRPTORMLST8DPP4DRD4 | |
| SCHEMBL20150230 | 0.88 | MTOR (0.77) | MTORRPTORMLST8DPP4DRD4 | |
| SCHEMBL21360294 | 0.87 | MTOR (0.76) | MTORRPTORMLST8DPP4DRD4 | |
| SCHEMBL21360389 | 0.87 | MTOR (0.76) | MTORRPTORMLST8DPP4DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089499-A1 | PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |