⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21894058 | 0.82 | — | — | |
| SCHEMBL7071890 | 0.78 | — | — | |
| SCHEMBL5545109 | 0.73 | — | — | |
| SCHEMBL21578173 | 0.73 | — | — | |
| SCHEMBL13827902 | 0.73 | KDM4E (0.37) | — | |
| SCHEMBL16949596 | 0.71 | — | — | |
| SCHEMBL15212591 | 0.71 | — | — | |
| SCHEMBL15657442 | 0.71 | — | — | |
| SCHEMBL19033006 | 0.70 | SLC6A2 (0.30) | — | |
| SCHEMBL17918748 | 0.70 | TAAR1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133200-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |