Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.30 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26620413 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBALDH1A1CYP1A2TDP1 | |
| SCHEMBL14818671 | 0.80 | SMN1; SMN2 (0.43) | SMN1; SMN2POLBALDH1A1CYP1A2TDP1 | |
| SCHEMBL22758461 | 0.79 | CYP1A2 (0.40) | SMN1; SMN2ALDH1A1CYP1A2TDP1PIK3CD | |
| SCHEMBL20738498 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1CYP1A2TDP1PIK3CD | |
| SCHEMBL25500305 | 0.75 | POLB (0.40) | POLBALDH1A1 | |
| SCHEMBL23231030 | 0.74 | USP2 (0.42) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL24811738 | 0.72 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1CYP1A2TDP1PIK3CD | |
| SCHEMBL24615831 | 0.72 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1CYP1A2TDP1PIK3CD | |
| SCHEMBL20148575 | 0.72 | SMN1; SMN2 (0.45) | SMN1; SMN2ALDH1A1CYP1A2TDP1PIK3CD | |
| SCHEMBL22350693 | 0.72 | SMN1; SMN2 (0.37) | SMN1; SMN2POLBCYP1A2TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180133200-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133200-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | SMN1; SMN2 833/4885POLB 3678/4885ALDH1A1 2868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.