Sugi Predict

Sugi Predict / Compounds / SCHEMBL20153189

SCHEMBL20153189

SCHEMBL20153189

CN1CC2CC(C1)N2C(=O)CC1CCOCC1

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ RET P07949 1/20 0.36
▸ EIF2AK4 Q9P2K8 1/20 0.33
▸ HRH3 Q9Y5N1 1/20 0.33
▸ PIK3CD O00329 3/20 0.32
▸ PIK3R2 O00459 2/20 0.32
▸ PIK3CA P42336 2/20 0.32
▸ PIK3CB P42338 2/20 0.32
▸ PIK3CG P48736 2/20 0.32
▸ PIK3R5 Q8WYR1 2/20 0.32
▸ PIK3R3 Q92569 2/20 0.32
▸ JAK3 P52333 2/20 0.32
▸ CCR2 P41597 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ RAB9A P51151 1/20 0.31
▸ CNR1 P21554 1/20 0.31
▸ CNR2 P34972 1/20 0.31
▸ TNKS2 Q9H2K2 1/20 0.31
▸ SMYD3 Q9H7B4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20154522 0.89 NAMPT (0.37) RETJAK3SMYD3
SCHEMBL23555338 0.85 RET (0.35) RETEIF2AK4JAK3CCR2KDM4E
SCHEMBL20070470 0.85 RET (0.35) RETHRH3PIK3CDJAK3CCR2
SCHEMBL22812266 0.84 RET (0.35) RETJAK3CCR2CNR1CNR2
SCHEMBL20160379 0.84 RET (0.38) RETEIF2AK4JAK3CCR2CNR1
SCHEMBL22030592 0.81 RET (0.35) RETPIK3CDJAK3CCR2
SCHEMBL20160380 0.80 RET (0.37) RETEIF2AK4JAK3CCR2CNR1
SCHEMBL14211232 0.79 SMYD3 (0.35) RETJAK3CNR1CNR2TNKS2
SCHEMBL22031247 0.76 PIK3CD (0.44) RETHRH3PIK3CDCCR2LMNA
SCHEMBL18731235 0.75 EIF2AK4 (0.37) EIF2AK4HRH3KDM4ELMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2024-02-29 — — US disclosed
US-20210186959-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA, INC. 2021-06-24 — — US disclosed
EP-3753939-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS Array Biopharma Inc. (US) 2020-12-23 — — EP disclosed
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180133200-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF RET 1/4885EIF2AK4 2060/4885HRH3 1148/4885
US-20210186959-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF RET 1/4885EIF2AK4 2060/4885HRH3 1148/4885
US-20240066029-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, ROR1, BRAF RET 1/4885EIF2AK4 2060/4885HRH3 1148/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.