Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 19/20 | 0.55 |
| ▸ | ITGB6 | P18564 | 17/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21311528 | 0.95 | ITGAV (0.57) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL20153294 | 0.88 | ITGAV (0.61) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL4194399 | 0.85 | ITGAV (0.61) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL20153293 | 0.84 | ITGAV (0.44) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL4249638 | 0.84 | ITGAV (0.64) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL20153469 | 0.84 | ITGAV (0.64) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL4196182 | 0.83 | ITGAV (0.60) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL20142613 | 0.82 | ITGAV (0.53) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL20153334 | 0.81 | ITGAV (0.67) | ITGAVITGB6ITGB3ITGB1ITGA5 | |
| SCHEMBL8226900 | 0.81 | ITGAV (0.58) | ITGAVITGB6ITGB3ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3538525-B1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2022-06-22 | — | — | EP | disclosed |
| WO-2018089353-A1 | 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-17 | — | — | WO | disclosed |