Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15618631 | 0.89 | CHRM1 (0.52) | CHRM1CHRM4CHRM2HRH3KDM5A | |
| SCHEMBL15618629 | 0.89 | CHRM1 (0.52) | CHRM1CHRM4CHRM2HRH3KDM5A | |
| SCHEMBL15618733 | 0.85 | CHRM1 (0.70) | CHRM1CHRM4CHRM2CHRM5LMNA | |
| SCHEMBL15618961 | 0.82 | CHRM1 (0.57) | CHRM1CHRM4CHRM2CHRM5 | |
| SCHEMBL17506708 | 0.82 | CHRM1 (0.44) | CHRM1CHRM4CHRM2HRH3KDM5A | |
| SCHEMBL17506709 | 0.82 | CHRM1 (0.44) | CHRM1CHRM4CHRM2HRH3KDM5A | |
| SCHEMBL14964784 | 0.81 | CHRM1 (0.73) | CHRM1HRH3LMNA | |
| SCHEMBL17254480 | 0.81 | CHRM1 (0.73) | CHRM1HRH3LMNA | |
| SCHEMBL15618708 | 0.78 | CHRM1 (0.69) | CHRM1CHRM4CHRM2LMNA | |
| SCHEMBL15630300 | 0.78 | CHRM1 (0.53) | CHRM1CHRM4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975890-B2 | Bicyclic AZA compounds as muscarinic M1 receptor antagonists | HEPTARES THERAPEUTICS LIMITED (GB) | 2018-05-22 | — | — | US | claimed |