Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 6/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20070420 | 0.91 | PIK3CD (0.49) | PIK3CDHRH3RETCCR2 | |
| SCHEMBL20160410 | 0.88 | PIK3CD (0.39) | PIK3CDHRH3RETCCR2GRM5 | |
| SCHEMBL21158721 | 0.84 | PIK3CD (0.36) | PIK3CDHRH3RETGRM5RIPK1 | |
| SCHEMBL20071302 | 0.84 | HRH3 (0.40) | PIK3CDHRH3CCR2 | |
| SCHEMBL24767230 | 0.82 | HRH3 (0.33) | HRH3 | |
| SCHEMBL20071310 | 0.81 | RECQL (0.44) | PIK3CDHRH3CCR2 | |
| SCHEMBL20148607 | 0.81 | RECQL (0.44) | PIK3CDHRH3CCR2GRM5 | |
| SCHEMBL23555271 | 0.81 | RET (0.35) | PIK3CDRETGRM5RIPK1 | |
| SCHEMBL23126226 | 0.81 | RET (0.37) | PIK3CDRETGRM5RIPK1 | |
| SCHEMBL21738110 | 0.80 | HRH3 (0.39) | PIK3CDHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240066029-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2024-02-29 | — | — | US | disclosed |
| US-10172851-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180133213-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
| US-20180134702-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134702-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | PIK3CD 1191/4885HRH3 1148/4885RET 1/4885 |
| US-10172851-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, ROR1, BRAF | PIK3CD 1191/4885HRH3 1148/4885RET 1/4885 |
| US-20180133213-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | PIK3CD 1191/4885HRH3 1148/4885RET 1/4885 |
| US-20240066029-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | PIK3CD 1191/4885HRH3 1148/4885RET 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.