Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 4/20 | 0.52 |
| ▸ | PAK4 | O96013 | 3/20 | 0.52 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.51 |
| ▸ | MERTK | Q12866 | 6/20 | 0.51 |
| ▸ | AXL | P30530 | 5/20 | 0.51 |
| ▸ | SELP | P16109 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.44 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.44 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154911 | 0.86 | TYRO3 (0.54) | PAK4TYRO3MERTKAXLSELP | |
| SCHEMBL20155274 | 0.81 | PLK4 (0.52) | PLK4PAK4TYRO3MERTKAXL | |
| SCHEMBL20155307 | 0.79 | TYRO3 (0.63) | PLK4PAK4TYRO3MERTKAXL | |
| SCHEMBL24158268 | 0.73 | TYRO3 (0.44) | TYRO3MERTKAXLSELPPRKAB2 | |
| SCHEMBL21299961 | 0.71 | PLK4 (0.50) | PLK4PAK4TYRO3MERTKAXL | |
| SCHEMBL21795974 | 0.69 | TYRO3 (0.79) | TYRO3MERTKAXLSELPFLT3 | |
| SCHEMBL30819919 | 0.69 | TYRO3 (0.79) | TYRO3MERTKAXLSELPFLT3 | |
| SCHEMBL20154970 | 0.69 | AXL (0.52) | PAK4TYRO3MERTKAXLSELP | |
| SCHEMBL13945047 | 0.68 | ITK (0.42) | PLK4PAK4IGF1R | |
| SCHEMBL21795923 | 0.67 | TYRO3 (1.00) | TYRO3MERTKAXLSELPCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3530656-B1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | UNIV ZHEJIANG (CN) | 2022-01-05 | — | — | EP | disclosed |
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | ZHEJIANG UNIVERSITY (CN) | 2020-11-03 | — | — | US | disclosed |
| EP-3530656-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | Zhejiang University (CN) | 2019-08-28 | — | — | EP | disclosed |
| WO-2018086547-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | CHEK1, CHEK2, PLK1 | PLK4 34/4885PAK4 131/4885TYRO3 719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.