SCHEMBL20154905

SCHEMBL20154905

BC(B)(c1ccc2c(c1)CC2)c1cc(C2CC(O)CC(CO)O2)ccc1Cl

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 5/20 0.36
SLC5A1 P13866 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20155258 0.88 SLC5A1 (0.37) SLC5A2SLC5A1
SCHEMBL20155224 0.86 SLC5A1 (0.39) SLC5A2SLC5A1
SCHEMBL20155240 0.85 SLC5A1 (0.39) SLC5A2SLC5A1
SCHEMBL22590725 0.77 SLC5A2 (0.62) SLC5A2SLC5A1
SCHEMBL20155568 0.76 SLC5A1 (0.39) SLC5A2SLC5A1
SCHEMBL20154898 0.74 SLC5A1 (0.41) SLC5A2SLC5A1
SCHEMBL20154892 0.72 SLC5A1 (0.43) SLC5A2SLC5A1
SCHEMBL19188789 0.70 SLC6A2 (0.47) SLC5A2
SCHEMBL12167159 0.68 SLC5A2 (0.53) SLC5A2SLC5A1
SCHEMBL20155579 0.68 SLC5A2 (0.46) SLC5A2SLC5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018089449-A1 BENZOCYCLOBUTANE DERIVATIVES USEFUL AS DUAL SGLT1/SGLT2 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2018-05-17 WO disclosed