Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 10/20 | 0.64 |
| ▸ | AXL | P30530 | 10/20 | 0.59 |
| ▸ | MERTK | Q12866 | 7/20 | 0.59 |
| ▸ | CCNK | O75909 | 3/20 | 0.54 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20155647 | 0.88 | TYRO3 (0.65) | TYRO3AXLMERTKCHEK1 | |
| SCHEMBL21795800 | 0.81 | TYRO3 (0.81) | TYRO3AXLMERTKIRAK4 | |
| SCHEMBL20155225 | 0.80 | AXL (0.82) | TYRO3AXLMERTKCHEK1IRAK4 | |
| SCHEMBL20155307 | 0.80 | TYRO3 (0.63) | TYRO3AXLMERTKIRAK4 | |
| SCHEMBL21795861 | 0.79 | TYRO3 (0.79) | TYRO3AXLMERTK | |
| SCHEMBL20154926 | 0.79 | TYRO3 (0.72) | TYRO3AXLMERTKIRAK4 | |
| SCHEMBL21795881 | 0.78 | TYRO3 (1.00) | TYRO3AXLMERTKCCNA2CDK2 | |
| SCHEMBL21796022 | 0.77 | TYRO3 (0.82) | TYRO3AXLMERTK | |
| SCHEMBL21795897 | 0.76 | TYRO3 (0.69) | TYRO3AXLMERTKIRAK4 | |
| SCHEMBL21795876 | 0.76 | TYRO3 (0.69) | TYRO3AXLMERTKIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3530656-B1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | UNIV ZHEJIANG (CN) | 2022-01-05 | — | — | EP | disclosed |
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | ZHEJIANG UNIVERSITY (CN) | 2020-11-03 | — | — | US | disclosed |
| EP-3530656-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | Zhejiang University (CN) | 2019-08-28 | — | — | EP | disclosed |
| WO-2018086547-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | CHEK1, CHEK2, PLK1 | TYRO3 719/4885AXL 466/4885MERTK 783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.