Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.65 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | LYN | P07948 | 2/20 | 0.56 |
| ▸ | PIM1 | P11309 | 2/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | BLK | P51451 | 2/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.56 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.56 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.56 |
| ▸ | AXL | P30530 | 4/20 | 0.53 |
| ▸ | MERTK | Q12866 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20154918 | 1.00 | CHEK1 (0.65) | CHEK1TYRO3CHEK2LCKLYN | |
| SCHEMBL20155640 | 1.00 | CHEK1 (0.65) | CHEK1TYRO3CHEK2LCKLYN | |
| SCHEMBL22617557 | 0.83 | IRAK4 (0.49) | CHEK1TYRO3CHEK2LCKLYN | |
| SCHEMBL20155301 | 0.81 | CHEK1 (0.65) | CHEK1TYRO3CHEK2LCKLYN | |
| SCHEMBL20155647 | 0.77 | TYRO3 (0.65) | CHEK1TYRO3AXLMERTK | |
| SCHEMBL20154977 | 0.76 | CHEK1 (0.60) | CHEK1TYRO3 | |
| SCHEMBL21299941 | 0.75 | CHEK1 (0.49) | CHEK1TYRO3 | |
| SCHEMBL21795881 | 0.74 | TYRO3 (1.00) | TYRO3AXLMERTK | |
| SCHEMBL21795861 | 0.74 | TYRO3 (0.79) | TYRO3AXLMERTK | |
| SCHEMBL21795800 | 0.74 | TYRO3 (0.81) | TYRO3AXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3530656-B1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | UNIV ZHEJIANG (CN) | 2022-01-05 | — | — | EP | disclosed |
| WO-2018086547-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |