SCHEMBL20155008

SCHEMBL20155008

COc1ncc(Br)c(N)c1C#C[Si](C)(C)C

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.30
CASP1 P29466 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20155403 0.84 MAPT (0.32) MAPTCASP1
SCHEMBL20155037 0.79 MAPT (0.30) MAPT
SCHEMBL31729119 0.79 RECQL (0.37) MAPTCASP1
SCHEMBL24343960 0.72 PDPK1 (0.36) MAPT
SCHEMBL14853026 0.72 MAPT (0.39) MAPTCASP1
SCHEMBL16475152 0.71 ALOX5AP (0.37) MAPTCASP1
SCHEMBL20155268 0.71 MAPT (0.36) MAPTCASP1
SCHEMBL20154968 0.70 NPC1 (0.37)
SCHEMBL17437073 0.69 MAPT (0.35) MAPTCASP1
SCHEMBL18370148 0.69 HTT (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018086604-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF 山东罗欣药业集团股份有限公司 2018-05-17 WO disclosed