Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.56 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21299941 | 0.91 | CHEK1 (0.49) | CHEK1IRAK4IRAK1 | |
| SCHEMBL20155618 | 0.89 | IRAK4 (0.56) | CHEK1IRAK4IRAK1MKNK1JAK2 | |
| SCHEMBL20154977 | 0.86 | CHEK1 (0.60) | CHEK1IRAK4 | |
| SCHEMBL20155229 | 0.84 | CHEK1 (0.60) | CHEK1IRAK4IRAK1 | |
| SCHEMBL21299968 | 0.84 | CHEK1 (0.58) | CHEK1IRAK4IRAK1 | |
| SCHEMBL24157949 | 0.81 | IRAK4 (0.66) | IRAK4IRAK1MKNK1JAK2JAK1 | |
| SCHEMBL20155301 | 0.78 | CHEK1 (0.65) | CHEK1IRAK4IRAK1 | |
| SCHEMBL20155270 | 0.76 | IRAK4 (0.67) | IRAK4IRAK1MKNK1 | |
| SCHEMBL28380262 | 0.75 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL20154921 | 0.74 | CHEK1 (0.48) | CHEK1IRAK4IRAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3530656-B1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | UNIV ZHEJIANG (CN) | 2022-01-05 | — | — | EP | disclosed |
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | ZHEJIANG UNIVERSITY (CN) | 2020-11-03 | — | — | US | disclosed |
| EP-3530656-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | Zhejiang University (CN) | 2019-08-28 | — | — | EP | disclosed |
| WO-2018086547-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10822327-B2 | 2-substituted aromatic ring-pyrimidine derivative and preparation and application thereof | CHEK1, CHEK2, PLK1 | CHEK1 1/4885IRAK4 839/4885IRAK1 679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.