Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.62 |
| ▸ | FLT3 | P36888 | 7/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21299944 | 0.77 | CHEK1 (0.44) | CHEK1 | |
| SCHEMBL20154886 | 0.76 | CHEK1 (0.70) | CHEK1FLT3PRKCQ | |
| SCHEMBL20155301 | 0.74 | CHEK1 (0.65) | CHEK1FLT3PRKCQ | |
| SCHEMBL24158266 | 0.74 | CHEK1 (0.64) | CHEK1FLT3PRKCQ | |
| SCHEMBL20155271 | 0.72 | CHEK1 (0.66) | CHEK1FLT3PRKCQ | |
| SCHEMBL28379428 | 0.72 | CHEK1 (1.00) | CHEK1FLT3 | |
| SCHEMBL20154994 | 0.69 | CHEK1 (0.60) | CHEK1FLT3PRKCQ | |
| SCHEMBL20154981 | 0.67 | CHEK1 (0.74) | CHEK1 | |
| SCHEMBL28379325 | 0.67 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL28387322 | 0.67 | CHEK1 (1.00) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086547-A1 | 2-SUBSTITUTED AROMATIC RING-PYRIMIDINE DERIVATIVE, AND PREPARATION AND APPLICATION THEREOF | 浙江大学 | 2018-05-17 | — | — | WO | disclosed |