⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18166881 | 0.79 | — | — | |
| SCHEMBL2379781 | 0.78 | — | — | |
| SCHEMBL10493348 | 0.78 | TP53 (0.44) | — | |
| SCHEMBL14666431 | 0.76 | — | — | |
| SCHEMBL20760887 | 0.76 | — | — | |
| SCHEMBL3222710 | 0.76 | — | — | |
| SCHEMBL14666393 | 0.76 | — | — | |
| SCHEMBL23020321 | 0.74 | TP53 (0.46) | — | |
| SCHEMBL21623887 | 0.74 | — | — | |
| SCHEMBL22080479 | 0.74 | TP53 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10280150-B2 | Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors | FORMA TM2, INC. (US) | 2019-05-07 | — | — | US | disclosed |
| US-20180134682-A1 | QUINOLINONE PYRIMIDINES COMPOSITIONS AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS | FORMA THERAPEUTICS, INC. | 2018-05-17 | — | — | US | disclosed |