Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 11/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 11/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 11/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20156834 | 0.87 | MTOR (0.54) | MTORRPTORMLST8DPP4PARP1 | |
| SCHEMBL20141003 | 0.84 | MTOR (0.54) | MTORRPTORMLST8DPP4PARP1 | |
| SCHEMBL20140926 | 0.84 | MTOR (0.54) | MTORRPTORMLST8DPP4PARP1 | |
| SCHEMBL20140996 | 0.81 | MTOR (0.44) | MTORRPTORMLST8DPP4PARP1 | |
| SCHEMBL20157088 | 0.79 | MTOR (0.49) | MTORRPTORMLST8DPP4PARP1 | |
| SCHEMBL20140721 | 0.79 | GRM1 (0.45) | MTORRPTORMLST8DPP4MAPT | |
| SCHEMBL20157490 | 0.79 | GRM1 (0.45) | MTORRPTORMLST8DPP4MAPT | |
| SCHEMBL20139904 | 0.79 | MTOR (0.48) | MTORRPTORMLST8DPP4PARP1 | |
| SCHEMBL20140350 | 0.79 | MTOR (0.54) | MTORRPTORMLST8PARP1LMNA | |
| SCHEMBL20140760 | 0.78 | MTOR (0.53) | MTORRPTORMLST8DPP4PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |