Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.59 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.59 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.59 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 7/20 | 0.42 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | DRD3 | P35462 | 5/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20141846 | 1.00 | MTOR (0.59) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20141016 | 0.96 | MTOR (0.53) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20157381 | 0.89 | MTOR (0.47) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20140800 | 0.89 | CHRM2 (0.53) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20157188 | 0.88 | MTOR (0.55) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20157186 | 0.88 | MTOR (0.55) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20156885 | 0.88 | MTOR (0.47) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20140914 | 0.88 | MTOR (0.47) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20140592 | 0.87 | MTOR (0.48) | MTORRPTORMLST8GRM1CHRM4 | |
| SCHEMBL20140650 | 0.87 | MTOR (0.48) | MTORRPTORMLST8GRM1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089433-A1 | PHENYL mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |