Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 17/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 17/20 | 0.54 |
| ▸ | RECQL | P46063 | 14/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 10/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.54 |
| ▸ | MITF | O75030 | 8/20 | 0.54 |
| ▸ | PKM | P14618 | 5/20 | 0.54 |
| ▸ | GFER | P55789 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 16/20 | 0.51 |
| ▸ | POLB | P06746 | 12/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.51 |
| ▸ | HTT | P42858 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | APEX1 | P27695 | 2/20 | 0.51 |
| ▸ | XBP1 | P17861 | 2/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14712884 | 0.80 | F2 (0.78) | F2MEN1KMT2ARECQLNPSR1 | |
| SCHEMBL13024523 | 0.78 | F2 (1.00) | F2MEN1KMT2ARECQLNPSR1 | |
| SCHEMBL1704746 | 0.78 | F2 (1.00) | F2MEN1KMT2ARECQLNPSR1 | |
| SCHEMBL1065724 | 0.78 | F2 (1.00) | F2MEN1KMT2ARECQLNPSR1 | |
| SCHEMBL23388506 | 0.71 | F2 (0.60) | F2MEN1KMT2ARECQLNPSR1 | |
| SCHEMBL23424282 | 0.71 | F2 (0.60) | F2MEN1KMT2ARECQLNPSR1 | |
| SCHEMBL9794744 | 0.70 | F2 (0.55) | F2MEN1KMT2ARECQLNPSR1 | |
| SCHEMBL20243737 | 0.70 | METAP1 (0.46) | MEN1KMT2ARECQLNPSR1MAPK1 | |
| SCHEMBL20243715 | 0.70 | DUSP3 (0.56) | F2MEN1KMT2ARECQLNPSR1 | |
| SCHEMBL9298131 | 0.69 | F2 (0.67) | F2MEN1KMT2ARECQLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180134691-A1 | BARBITURATE AND THIOBARBITURATE COMPOUNDS FOR USE IN CANCER THERAPY | NUHOPE, LLC (US) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134691-A1 | BARBITURATE AND THIOBARBITURATE COMPOUNDS FOR USE IN CANCER THERAPY | MGMT, BCL2, BAX | F2 4684/4885MEN1 2410/4885KMT2A 2749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.